BI1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | BI1 |
| Clone | 20F430 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 0.5 mg/mL |
| Applications | Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Bi-1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Bi-1 from human, mouse and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Bi-1 from other sources has not been determined. Anti-Bi-1 antibody detects human Bi-1. BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER. Anti-Bi-1 antibody is ideal for investigators involved in apoptosis research. |
| Immunogen | Bi-1 Antibody was produced in mice prepared by repeated immunizations of a mixture of three synthetic peptides corresponding to the N-terminus, internal and C-terminus of human Bi-1 protein. |
| Other Names | BI1, TEGT, Bax inhibitor 1, BI-1, Testis-enhanced gene transcript protein,Transmembrane BAX inhibitor motif-containing protein 6 |
| Gene, Accession # | TMBIM6, Gene ID: 7009, NCBI: NP_001092046.1, UniProt: P55061 |
| Catalog # | 200-301-H60 |
| Price | $525 |
| Order / More Info | BI1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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