Receptor-interacting serine-threonine kinase 3 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Receptor-interacting serine-threonine kinase 3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Receptor-interacting serine-threonine kinase 3 Antibody was purified by affinity chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Receptor-interacting serine-threonine kinase 3 from human and chimpanzee based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Receptor-interacting serine-threonine kinase 3 from other sources has not been determined. Anti-Receptor-interacting serine-threonine kinase 3 antibody detects human RIP3. RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2. Anti-Receptor-interacting serine-threonine kinase 3 Antibody is ideal for investigators involved in apoptosis and NFkappaB research. |
| Immunogen | Receptor-interacting serine-threonine kinase 3 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the c-terminus of human Receptor-interacting serine/threonine-protein kinase 3. |
| Other Names | RIP3, Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3 |
| Gene, Accession # | RIPK3, Gene ID: 11035, NCBI: NP_006862.2, UniProt: Q9Y572 |
| Catalog # | 600-401-I08 |
| Price | $495 |
| Order / More Info | Receptor-interacting serine-threonine kinase 3 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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