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Antigenic Specificity | ZNF536 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-ZNF536 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ZNF536 from other sources has not been determined. ZNF536 is a recently identified zinc-finger protein that is expressed primarily in the developing nervous system and the cerebral cortex, hippocampus, and hypothalamus. ZNF536 possess ten zinc fingers and interacts with CtBP1, a corepressor for gene transcription. It is most closely related to transcriptional repressor ZNF219. Overexpression of ZNF536 in embryonic stem cells dramatically reduced the mRNA levels of neuronal marker genes such as Pax6, MAP2, and beta-tubulin III following retinoic acid (RA)-induced differentiation, while depletion of ZNF536 via RNAi resulted in elevated mRNA levels of these genes, indicating its role in inhibiting neuronal cell differentiation. Overexpression of RA receptor a rescues the inhibitory role of ZNF536, suggesting that ZNF536 might inhibit RA response element-mediated transcriptional activity. |
Immunogen | Anti-ZNF536 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the N-terminus of human ZNF536. |
Other Names | ZNF536 Antibody, KIAA0390, Zinc finger protein 536 |
Gene, Accession # | ZNF536, Gene ID: 9745, NCBI: NP_055532.1, UniProt: O15090 |
Catalog # | 600-401-GG4 |
Price | $475 |
Order / More Info | ZNF536 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |