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Antigenic Specificity | MD-2 |
Clone | 1A2E3 |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1 |
Format | Protein A purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-MD-2 Monoclonal Antibody was Protein A purified. Cross reactivity with MD-2 [1A2E3] from other sources has not been determined. MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4. |
Immunogen | Anti-MD-2 antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to amino acids 2 to 160 of human MD-2 |
Other Names | MD-2 Antibody [1A2E3] , MD2, MD-2, ly-96, ESOP-1 |
Gene, Accession # | LY96, Gene ID: 23643, NCBI: NP_056179, UniProt: Q9Y6Y9 |
Catalog # | 200-301-CS4 |
Price | $485 |
Order / More Info | MD-2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |