APAF1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | APAF1 |
| Clone | 5E11 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Apaf-1 Monoclonal Antibody was immunoaffinity chromatography purified IgG. Cross reactivity with Apaf-1 [5E11] from other sources has not been determined. Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues. |
| Immunogen | Anti-Apaf1 antibody was produced by repeated immunizations in mice with peptide corresponding to amino acids near the C-terminus of human Apaf1. |
| Other Names | Apaf-1 Antibody [5E11] , CED4, APAF-1 |
| Gene, Accession # | APAF1, Gene ID: 317, NCBI: AAC51678, UniProt: O14727 |
| Catalog # | 200-301-Y28 |
| Price | $485 |
| Order / More Info | APAF1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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