Histone H3 phospho S28 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Histone H3 phospho S28 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 50 µg |
| Concentration | 0.96 mg/ml |
| Applications | Chip, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Histone H3 [p Ser28] was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with human Histone H3. A BLAST analysis was used to suggest cross-reactivity with Human, mouse, and C. elegans. Predicted to react with many species including rat, chicken, Xenopus, Drosophila, and plant based on 100% sequence homology. Cross-reactivity with Histone H3 from other sources has not been determined. Chromatin is the arrangement of DNA and proteins in which chromosomes are formed. Correspondingly, chromatin is formed from nucleosomes, which are comprised of a set of four histone proteins (H2A, H2B, H3, H4) wrapped with DNA. Chromatin is a very dynamic structure in which numerous post-translational modifications work together to activate or repress the availability of DNA to be copied, transcribed, or repaired. These marks decide which DNA will be open and commonly active (euchromatin) or tightly wound to prevent access and activation (heterochromatin). Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine. In particular, phosphorylation of serine 28 of H3 (H3 pS28) is a mitotic and immediate early gene marker. Although similar to phosphorylation on serine 10 of H3 in the role of chromatin condensation in mitosis and the ability to respond to external stimuli such as stress and mitogen activation, these two phosphorylation sites are independent and promote gene expression separately. Phosphorylation of S28 is modulated by MSK1, MSK2, and Aurora-B kinase. Anti-Histone H3 are ideal for researchers interested in Chromatin Research, Epigenetics, Chromatin Modifiers, Histones and Modified Histones research. |
| Immunogen | Histone H3 [p Ser28] affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic phosphorylated peptide surrounding Serine 28 of human Histone H3. |
| Other Names | rabbit anti-Histone H3 pS28 antibody, H3.3B, H3.3AH3F3H3F3B, H3 histone, family 3A, histone H3.3, MGC87782, MGC87783, H3pS28 |
| Gene, Accession # | HIST2H3C, Gene ID: 126961, NCBI: NP_001005464, UniProt: Q71DI3 |
| Catalog # | 600-401-I83 |
| Price | $495 |
| Order / More Info | Histone H3 phospho S28 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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