AIF Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | AIF |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-AIF Antibody is directed against human AIF protein. The product is affinity chromatography purified via peptide column. A BLAST analysis was used to suggest cross-reactivity with AIF protein from mouse and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known. Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of the caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like cytochrome c and caspase-9, which are critical molecules in apoptosis, AIF localizes to mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis. These effects occur in both isolated nuclei and in the nuclei of live cells treated by microinjection and with apoptosis stimuli. AIF is highly conserved between human and mouse and is widely expressed. Anti-AIF antibody is ideal for investigators involved in DNA Damage and Repair and Chromatin research. |
| Immunogen | AIF Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids at an internal region of human AIF protein. |
| Other Names | Harlequin antibody, Hq antibody, mAIF antibody, MGC111425 antibody, MGC5706 antibody, PDCD 8 antibody, AIF, PDCD8 |
| Gene, Accession # | AIFM1, Gene ID: 9131, NCBI: NP_001124318.2, UniProt: O95831 |
| Catalog # | 200-401-985 |
| Price | $475 |
| Order / More Info | AIF Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 26178079 // 31452759 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.