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Antigenic Specificity | CXCR3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-CXCR3 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. CXCR3 antibody is human, mouse and rat reactive. At least two isoforms of CXCR3 are known to exist; this antibody will detect both isoforms. The CXCR3 protein is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-gamma), CXCL10/IP10 (interferon-gamma-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell alpha-chemoattractant) (reviewed in 1). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration (2). Similar to other chemokine receptors such as CXCR4, CXCR3 has been implicated in several malignancies as a biomarker of tumor behavior as well as a potential therapeutic target (3). |
Immunogen | Anti-CXCR3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid peptide near the C-terminus of human CXCR3 |
Other Names | CXCR3 Antibody, GPR9, MigR, CD182, CD183, Mig-R, CKR-L2, CMKAR3, IP10-R, GPR9, C-X-C chemokine receptor type 3, CXC-R3 |
Gene, Accession # | CXCR3, Gene ID: 2833, NCBI: NP_001136269, UniProt: P49682 |
Catalog # | 600-401-AR4 |
Price | $475 |
Order / More Info | CXCR3 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |