Troponin I (cardiac) Phospho S23/24 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Troponin I (cardiac) Phospho S23/24 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified, no preservative |
| Size | 100 µL |
| Concentration | Sufficient to run approximately 10 tests |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Phospho-Ser23/24 Troponin (cardiac) Antibody is directed against Troponin protein phosphorylated at S23 and S24. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated Troponin. Minimal reactivity occurs against non-phosphorylated Troponin. Reactivity against Troponin occurs from mouse sources. However, reactivity is also expected against human and non-human primate based on 100% sequence homology. Troponin I (cTnI) is 1 of 3 subunits, along with troponin C (TnC) and troponin T (TnT) of troponin complex found in cardiac muscle. cTnI binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place, and when cTnI is phosphorylated by protein kinase C and protein kinase A at Ser23/24 it causes regulation of Ca2+- stimulated ATPase. Evidence suggests that phosphorylation of both serines 23 and 24 is required for the reduction in Ca2+-sensitivity and beneficial for relaxation of the heart. Ser23/24 phosphorylation is important for enhanced relaxation in response to prolonged activation of protein kinase C by endothelin in intact myocytes, while Thr144 plays an important role in the acute acceleration of relaxation. Troponin I pS23/24 Antibody is ideal for researchers interested in cancer research. |
| Immunogen | Anti-Phospho-Ser23/24 Troponin (cardiac) Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser23/24 of mouse cardiac troponin I conjugated to KLH. |
| Other Names | Troponin I cardiac muscle, Cardiac troponin I |
| Gene, Accession # | Tnni3, Gene ID: 21954, NCBI: NP_033432.1, UniProt: P48787 |
| Catalog # | 600-401-X32 |
| Price | $475 |
| Order / More Info | Troponin I (cardiac) Phospho S23/24 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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