NMDA NR2A Subunit Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | NMDA NR2A Subunit |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 10 µg |
| Concentration | Titrated value sufficient to run approximately 10 mini blots. |
| Applications | Immunohistochemistry, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-NMDA NR2A Subunit antibody is directed against NMDA NR2A protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. NMDA NR2A antibody recognizes human, mouse and rat forms of the NR2A subunit of NMDAR. The antibody does not cross react towards NR2B and NR2C subunits. Immunolabeling is blocked by pre-adsorption of antibody with the fusion protein used to generate the antibody. NMDA NR2A Subunit antibody detects NMDA NR2A protein. The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Anti-NMDA NR2A Subunit Antibody is ideal for investigators involved in Neuroscience and Signal Transduction research. |
| Immunogen | Anti-NMDA NR2A subunit Antibody was produced by repeated immunizations with a fusion protein from the C-terminal region of the NR2A subunit. |
| Other Names | Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, Grin2a |
| Gene, Accession # | Grin2a, Gene ID: 24409, NCBI: NP_036705.3, UniProt: Q00959 |
| Catalog # | 600-401-C86 |
| Price | $475 |
| Order / More Info | NMDA NR2A Subunit Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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