BACE Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | BACE |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | ion exchange purified |
| Size | 100 µg |
| Concentration | 1.0 mg/ml |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-BACE Antibody is purified by ion exchange chromatography. Cross reactivity with BACE from other sources has not been determined. Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP. |
| Immunogen | Anti-BACE antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to 17 amino acids at the C-terminus of human BACE. The immunogen is located within the last 50 amino acids of BACE. |
| Other Names | BACE Antibody, ASP2, BACE, HSPC104, KIAA1149, Beta-secretase 1, Aspartyl protease 2, ASP2 |
| Gene, Accession # | BACE1, Gene ID: 23621, NCBI: AF190725, UniProt: P56817 |
| Catalog # | 200-401-Z18 |
| Price | $475 |
| Order / More Info | BACE Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 20854419 // 31479861 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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