SAP102 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | SAP102 |
| Clone | S19-2 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | Immunohistochemistry, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-SAP102 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with SAP102 from Human, Mouse, and Rat based on 100% homology with the immunizing sequence. No cross-reactivity against PSD95, SAP97 or Chapsyn-110. Cross-reactivity with SAP102 from other sources has not been determined. Organelle Markers, Neurobiology research. Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal. SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homology 3 domain and a guanylate kinase domain. All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway. SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains. In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth. |
| Immunogen | SAP102 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to an n-terminal region of rat SAP102. |
| Other Names | DLG3, MRX90, NEDLG, XLMR, Disks large homolog 3, PSD-95/SAP90-related protein 1, Synapse-associated protein 102, SAP-102 |
| Gene, Accession # | Dlg3, Gene ID: 58948, NCBI: NP_113827.1, UniProt: Q62936 |
| Catalog # | 200-301-G38 |
| Price | $485 |
| Order / More Info | SAP102 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 31295463 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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