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Antigenic Specificity | GGA2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.4 mg/mL |
Applications | ELISA, Immunoprecipitation, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This is an affinity purified antibody produced by immunoaffinity chromatography using the immunizing peptide after immobilization to a solid phase. GGA-2 plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. It mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain that mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. |
Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 240-270 of Human GGA2. SwissProt accession Q9UJY4. Expected to cross-react with mouse. |
Other Names | rabbit anti-GGA-2 antibody, GGA2, GGA 2, Golgi associated gamma adaptin ear containing ARF binding protein 2, ADP-ribosylation factor-binding protein GGA2, Gamma-adaptin-related protein 2, VHS domain and ear domain of gamma-adaptin, Vear |
Gene, Accession # | GGA2, Gene ID: 23062, NCBI: NP_055859.1, UniProt: D3DWF0 |
Catalog # | 600-401-849 |
Price | $475 |
Order / More Info | GGA2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |