SNAP25 Phospho S187 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
Search, find, compare suppliers for anti-SNAP25 Phospho S187 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | SNAP25 Phospho S187 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified, no preservative |
| Size | 100 µL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Phospho-Ser187 SNAP25 Antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated SNAP25. Minimal reactivity occurs against non-phosphorylated SNAP25. Reactivity against SNAP25 occurs from rat sources. However, reactivity is also expected against guinea pig, human, non-human primate, zebra fish based on 100% sequence homology. SNAP25 (Synaptosomal associated protein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer's Disease. In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia. Increasing evidence suggests that SNAP-25 also modulates various ion channels, including voltage gated calcium channels (VGCCs). Activation of PKC results in the phosphorylation of SNAP-25 on ser187. Phosphorylation of SNAP25 on ser187 is believed to cause inhibition of VGCC. Since ser187 phosphorylation is transiently induced by neuronal activity, SNAP25 creates a negative feedback mechanism for controlling neuronal excitability. SNAP25 pS187 Antibody is ideal for researchers interested in neuroscience research. |
| Immunogen | Anti-Phospho-Ser187 SNAP25 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser187 of rat SNAP25 conjugated to KLH. |
| Other Names | Synaptosomal-associated protein 25, SNAP-25, Super Protein, SUP, Synaptosoma-associated 25 kDa protein |
| Gene, Accession # | Snap25, Gene ID: 25012, NCBI: NP_001257504.1, UniProt: P60881 |
| Catalog # | 600-401-X28 |
| Price | $475 |
| Order / More Info | SNAP25 Phospho S187 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.
Return to Antibodies