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Antigenic Specificity | Raf-1 phospho S301 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µL |
Concentration | n/a |
Applications | Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Raf-1 pS301 antibodies are affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected the following species based on 100% sequence homology: bovine, canine, chicken, mouse, non-human primate and Xenopus. Raf-1 pS301 antibody detects phosphorylated Raf-1. The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK. Previous studies have shown that phosphorylation is required for Raf-1 activation. Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf with two sites participating: Ser301 and Ser642. Anti-Raf-1 pS301 Antibody is ideal for investigators involved in Cancer, Neuroscience, Signal Transduction research. |
Immunogen | Anti-Raf-1 pS301 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser301 conjugated to KLH. |
Other Names | RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, cRaf |
Gene, Accession # | Raf1, Gene ID: 24703, UniProt: P11345 |
Catalog # | 600-401-E23 |
Price | $475 |
Order / More Info | Raf-1 phospho S301 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |