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Antigenic Specificity | Synaptotagmin phospho T202 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µL |
Concentration | n/a |
Applications | Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Synaptotagmin 1 pT202 Antibody is directed against rat Synaptotagmin 1 phosphorylated at T202 residue. Synaptotagmin antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, chicken, human, mouse, non-human primate and zebra fish. Cross-reactivity with from other species has not been determined. Synaptotagmin 1 pT202 Antibody detects Synaptotagmin 1, which is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS. It is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Recent studies indicate that synaptotagmin's Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane fusion. It has recently been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin can be phosphorylated by multiple protein kinases and this may play a key role in modulation of synaptotagmin's ability to influence both the exocytotic and endocytotic components of synaptic transmission. Anti-Synaptotagmin 1 pT202 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research. |
Immunogen | Anti-Synaptotagmin pT202 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Thr202 of synaptotagmin. |
Other Names | Synaptotagmin-1, Synaptotagmin I, SytI, p65, Syt1 |
Gene, Accession # | Syt1, Gene ID: 25716, UniProt: P21707 |
Catalog # | 612-401-E38 |
Price | $475 |
Order / More Info | Synaptotagmin phospho T202 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |