MyD88 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | MyD88 |
| Clone | 2E9C2 |
| Host Species | Mouse |
| Reactive Species | human, mouse |
| Isotype | IgG2b |
| Format | Protein A purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-MyD88 Monoclonal Antibody was Protein A purified. Cross reactivity with MyD88 [2E9C2] from other sources has not been determined. The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues. |
| Immunogen | Anti-MyD88 antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to amino acids 176 to 280 of human MyD88. |
| Other Names | MyD88 Antibody [2E9C2] , MYD88D |
| Gene, Accession # | MYD88, Gene ID: 4615, NCBI: U70451, UniProt: Q99836 |
| Catalog # | 200-301-CW6 |
| Price | $485 |
| Order / More Info | MyD88 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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