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Antigenic Specificity | Esrp-2 |
Clone | 22C5.H7.A6 |
Host Species | Mouse |
Reactive Species | mouse |
Isotype | IgG2a kappa |
Format | IgG fraction |
Size | 25 µL |
Concentration | 1.0 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This product is an IgG fraction antibody purified from tissue culture supernatant by Protein-A chromatography followed by extensive dialysis against the buffer stated above. This antibody reacts with mouse Esrp-2 protein. A BLAST analysis was used to suggest cross-reactivity with Esrp-2 from mouse based on a 100% homology with the immunizing sequence. Cross-reactivity with Esrp-2 from other sources has not been determined. Epithelial splicing regulatory protein 2 (Esrp-2) is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-2 acts by directly binding specific sequences in mRNAs. It binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. |
Immunogen | Anti-Esrp-2 is produced by repeated immunizations of full length recombinant mouse Esrp-2 fusion protein. |
Other Names | mouse anti-Esrp2 antibody, mouse anti-Ersp-2 antibody, RNA-binding protein 35B, RNA-binding motif protein 35B |
Gene, Accession # | Esrp2, Gene ID: 77411, NCBI: NCBI, UniProt: Q8K0G8 |
Catalog # | 210-301-C32S |
Price | $125 |
Order / More Info | Esrp-2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | PubMed: 28759043 |