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Antigenic Specificity | Cyclin O |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Cyclin O Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least two isoforms of Cyclin O are known to exist; this antibody will recognize both isoforms. Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to intrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Suppression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member. |
Immunogen | Anti-Cyclin O antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the N-terminus of human Cyclin O. |
Other Names | Cyclin O Antibody, CCNU, UDG2, Cyclin-O |
Gene, Accession # | CCNO, Gene ID: 10309, NCBI: NP_066970, UniProt: P22674 |
Catalog # | 600-401-AR8 |
Price | $475 |
Order / More Info | Cyclin O Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |