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Antigenic Specificity | KLRA1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-KLRA1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least three isoforms of KLRA1 are known to exist; this antibody recognizes only the long isoform. KLRA1 (also known as Ly49L) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA1 is thought to be an activating receptor, inducing DAP12 phosphorylation in response to antibody-mediated cross-linking of KLRA1 on NK cells. |
Immunogen | Anti-KLRA1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 13 amino acid synthetic peptide near the internal region of human KLRA1. |
Other Names | KLRA1 Antibody, Ly49, KLRA#, KLRA1, LY49L, Ly-49L |
Gene, Accession # | KLRA1, Gene ID: 10748, NCBI: EAW96194 |
Catalog # | 600-401-CF6 |
Price | $475 |
Order / More Info | KLRA1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |