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Antigenic Specificity | AKT1S1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-AKT1S1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. AKT1S1 antibody is human, mouse and rat reactive. At least three isoforms of AKT1S1 are known to exist. The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia (1). AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy (2). Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells (3). |
Immunogen | Anti-AKT1S1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid peptide near the C-terminus of human AKT1S1. |
Other Names | AKT1S1 Antibody, Lobe, PRAS40, Proline-rich AKT1 substrate 1, 40 kDa proline-rich AKT substrate |
Gene, Accession # | AKT1S1, Gene ID: 84335, NCBI: NP_115751, UniProt: Q96B36 |
Catalog # | 600-401-Y00 |
Price | $475 |
Order / More Info | AKT1S1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |