Tryptophan Hydroxylase 1 phospho S58 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Tryptophan Hydroxylase 1 phospho S58 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | rabbit |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Tryptophan Hydroxylase pS58 Antibody is directed against phosphorylated rat Tryptophan Hydroxylase protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification and is specific for the phosphorylated protein. Reactivity is expected from the following species based on 100% sequence homology: bovine, chicken, human, mouse, non-human primate, rat, xenopus, and zebra fish. Tryptophan Hydroxylase pS58 Antibody detects phosphorylated Tryptophan Hydroxylase protein. Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II). Both PKA and CaM K II phosphorylate Ser58 which lies within the regulatory domain of TPH. |
| Immunogen | Anti-Tryptophan Hydroxylase pS58 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser58. |
| Other Names | Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1 |
| Gene, Accession # | Tph1, Gene ID: 24848, NCBI: 1094104.1, UniProt: P09810 |
| Catalog # | 600-401-C97 |
| Price | $475 |
| Order / More Info | Tryptophan Hydroxylase 1 phospho S58 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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