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Antigenic Specificity | ZFP219 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-ZFP219 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least two isoforms of ZFP219 are known to exist; this antibody will recognize both. ZFP219 is a developmentally regulated member of the Kruppel-like zinc finger gene family that is thought to function as a transcriptional repressor. Yeast two-hybrid screening showed association with Sox9, a transcription factor that is essential for chondrogenesis. ZFP219 is specifically expressed in the developing limb buds and colocalizes with Sox9 in the nucleus. Knockdown of ZFP219 expression decreased Sox9-induced mRNA expression, and a dominant-negative mutant of ZFP219 inhibited Bmp2-induced chondrocyte differentiation, suggesting that ZFP219 plays an important role as a transcriptional partner of Sox9 in the regulation of chondrocyte differentiation. |
Immunogen | Anti-ZFP219 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the N-terminus of human ZFP219. |
Other Names | ZFP219 Antibody, ZFP219, Zinc finger protein 219 |
Gene, Accession # | ZNF219, Gene ID: 51222, NCBI: NP_001095142.1, UniProt: Q9P2Y4 |
Catalog # | 600-401-GD3 |
Price | $475 |
Order / More Info | ZFP219 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |