CCR5 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | CCR5 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-CCR5 Antibody is affinity chromatography purified via peptide column. A BLAST analysis was used to suggest cross-reactivity with CCR5 with Human based on 100% homology with the immunizing sequence. Cross-reactivity with CCR5 from other sources has not been determined. CCR5 antibody detects a G coupled -protein receptor. Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes. Anti-CCR5 antibodies are ideal for investigators involved in Cytokines and Growth Factors and Infectious Disease research. |
| Immunogen | CCR5 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to an internal region of human CCR5. |
| Other Names | CMKBR5, C-C chemokine receptor type 5, CHEMR13, HIV-1 fusion coreceptor, CD195 |
| Gene, Accession # | CCR5, Gene ID: 1234, NCBI: NP_000570.1, UniProt: P51681 |
| Catalog # | 200-401-G87 |
| Price | $475 |
| Order / More Info | CCR5 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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