Nitric Oxide Synthase (NOS1) Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Nitric Oxide Synthase (NOS1) |
| Clone | NOS-B1 |
| Host Species | Mouse |
| Reactive Species | human, rat, goat, porcine |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-NOS1 antibody was purified from mouse ascites by protein A chromatography. This product reacts with human, rat, goat, and pig. Cross reactivity with NOS1 from other sources has not been determined. Nitric Oxide Synthase 1(NOS1,neuronal NOS,nNOS1) is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. It may be involved in neuronal cell death and damage in neurological illness. nNOS1 localized to the 12q24.2 region of human chromosome 12. It splice variant, expressed in testis, that encodes an NH2-terminal truncated protein of 1098 amino acids. nNOS cDNA clones were shown to contain different 5' terminal exons spliced to a common exon 2. Genomic cloning and sequence analysis demonstrate that the unique exons are positioned within 300 bp of each other but separated from exon 2 by an intron that is at least 20 kb in length. The neuronal isoform of nitric oxide synthase is highly expressed in mammalian skeletal muscle, it suggested a specific role for NOS1 in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle. The novel gaseous neuromediator nitric oxide is thought to play an important role in development and plasticity. Despite this, gene-knockout mice lacking neuronal (Type I) nitric oxide synthase exhibit relatively normal brain development and behavior. This antibody is suitable for researchers interested in apoptosis research, cell death, and TNF pathways. |
| Immunogen | Nitric Oxide Synthase (NOS1) antibody was produced in mice by repeated immunizations with recombinant protein corresponding to neuronal NOS fragment (amino acids 1-181) from rat brain. |
| Other Names | NOS, bNOS, nNOS, IHPS1, N-NOS, NC-NOS, Neuronal NOS, Peptidyl-cysteine S-nitrosylase NOS1 |
| Gene, Accession # | NOS1, Gene ID: 4842, NCBI: NP_000611.1, UniProt: P29475 |
| Catalog # | 200-301-P43 |
| Price | $485 |
| Order / More Info | Nitric Oxide Synthase (NOS1) Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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