Ire1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Ire1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1.0 mg/ml |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This affinity purified antibody is directed against mouse Ire1. This product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to human.. Inositol-requiring enzyme 1 (IRE1) or ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) is a Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain, and subsequent activation of the endoribonuclease activity. The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA. The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes. Diseases associated with ERN1 include Chromosome 6Pter-P24 Deletion Syndrome and Alzheimer Disease. Anti-IRE1 Antibody is useful for researchers interested in Neuroscience research. |
| Immunogen | Anti-Ire1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal portion of mouse Ire1 conjugated to Keyhole Limpet Hemocyanin (KLH). |
| Other Names | Rabbit Anti-Ern1 Antibody, Rabbit Anti-Endoplasmic Reticulum To Nucleus Signaling 1 Antibody, Rabbit Anti-IRE1 Antibody, Endoplasmic Reticulum To Nucleus Signaling 1, Serine/Threonine-Protein Kinase/Endoribonuclease IRE1, Inositol-Requiring Protein 1, Inositol-Requiring Enzyme 1, ER To Nucleus Signalling 1, Ire1-Alpha, HIRE1p, IRE1a, IRE1, Endoplasmic Reticulum-To-Nucleus Signaling 1, Protein Kinase/Endoribonuclease, Inositol-Requiring 1, IRE1P |
| Gene, Accession # | Ern1, Gene ID: 78943, NCBI: NP_076402.1, UniProt: Q9EQY0 |
| Catalog # | 600-401-HB9 |
| Price | $475 |
| Order / More Info | Ire1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.