CD8a Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | CD8a |
| Clone | 2.43 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2b kappa |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 µg |
| Concentration | 0.2 mg/mL |
| Applications | Flow Cytometry, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Allophycocyanin conjugated CD8a Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against mouse CD8a. Cross reactivity with CD8a from other sources has not been tested. Anti-CD8a is conjugated with APC under optimal conditions and the solution is free of unconjugated APC. CD8a antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites. The 2.43 antibody is widely used as a phenotypic marker for mouse CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. |
| Immunogen | Anti-CD8a Antibody (Monoclonal) was produced by repeated immunizations with CD8a antigen. |
| Other Names | T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, Cd8a, Lyt-2, Lyt2 |
| Gene, Accession # | Cd8a, Gene ID: 12525, NCBI: NP_001074579.1, UniProt: P01731 |
| Catalog # | 200-526-N78 |
| Price | $495 |
| Order / More Info | CD8a Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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