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Antigenic Specificity | TMEM59L |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-TMEM59L Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59. Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding. |
Immunogen | Anti-TMEM59L antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide near C-terminus of human TMEM59L. |
Other Names | TMEM59L Antibody, BSMAP, C19orf4, BSMAP, Transmembrane protein 59-like, Brain-specific membrane-anchored protein |
Gene, Accession # | TMEM59L, Gene ID: 25789, NCBI: NP_036241.1, UniProt: Q9UK28 |
Catalog # | 600-401-FJ9 |
Price | $475 |
Order / More Info | TMEM59L Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |