CD28 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | CD28 |
| Clone | CD28.2 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | allophycocyanin (APC) conjugate |
| Size | 500 µL |
| Concentration | 0.05 mg/mL |
| Applications | Flow Cytometry, Immunohistochemistry, Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Allophycocyanin conjugated CD28 Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against human CD28. Reactivity is observed against human CD28, Baboon, Chimpanzee, Cynomolgus, and Rhesus. Cross reactivity with CD28 from other sources has not been tested. Anti-CD28 is conjugated with APC under optimal conditions and the solution is free of unconjugated APC. The CD28 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA. The CD28.2 antibody may be used as a phenotypic marker for human CD28, expressed on all CD4+ T cells and CD8+ T cells, and is widely used as a reagent for activation of the CD28 receptor in vitro and in vivo. |
| Immunogen | Anti-CD28 Antibody (Monoclonal) was produced by repeated immunizations with CD28 antigen. |
| Other Names | T-cell-specific surface glycoprotein CD28, TP44, CD28 |
| Gene, Accession # | CD28, Gene ID: 940, NCBI: NP_001230006.1, UniProt: P10747 |
| Catalog # | 200-326-N66 |
| Price | $495 |
| Order / More Info | CD28 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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