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Antigenic Specificity | TrkCT1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.0 mg/mL |
Applications | ELISA, Immunoprecipitation, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This affinity purified antibody is directed against mouse TrkCT1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with TrkCT1 protein from human, mouse and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known. This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. TrkCT1, also named neurotrophic tyrosine kinase receptor type 3 (Ntrk3) non-catalytic isoform 2, is a non-catalytic isoform of TrkC, the high affinity receptor for Neurotrophin-3 (NT-3). This isoform lacks the kinase domain that is responsible for signaling by the full-length isoform. TrkCT1 is the product of an alternative splicing of Ntrk3 that leaves the extracellular and transmembrane domains intact but includes a shorter intracellular domain encoded by exons 13b and 14b. Recent studies indicate that the short cytoplasmic tail binds the scaffold protein Tamalin in a ligand-dependent manner and further activates the Arf6-Rac1 signaling pathway. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads. |
Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse TrkCT1 protein. |
Other Names | rabbit anti-TrkCT1 antibody, rabbit anti-Ntrk3 antibody, TrkCT-1, NT-3 growth factor receptor, GP145-TrkC, Trk-C, ETV6 NTRK3 fusion antibody, GP145 TrkC antibody, GP145TrkC antibody, Neurotrophic tyrosine kinase receptor type 3 antibody, TrkC tyrosine kinase, TrkC NC2 |
Gene, Accession # | Ntrk3, Gene ID: 18213, NCBI: 33413429, UniProt: Q6VNS1 |
Catalog # | 600-401-993 |
Price | $475 |
Order / More Info | TrkCT1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | PubMed: 34360553 |