Smac/Diablo Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Smac/Diablo |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | serum |
| Size | 100 µL |
| Concentration | 85 mg/mL |
| Applications | ELISA, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antiserum is directed against human Smac/DIABLO and is useful in determining its presence in various assays. Apoptosis is a conserved cell suicide program essential for the development and homeostasis of multi-cellular organisms. Abnormal inhibition of apoptosis is a hallmark of cancer and autoimmune diseases, whereas excessive cell death is found in neurodegenerative disorders such as Alzheimers disease. Executioners of the apoptotic program are cysteine proteases termed caspases that exist as inactive zymogens in living cells and are activated during apoptosis. Active caspases cleave key intracellular protein substrates, resulting in the characteristic morphological changes associated with apoptosis. The release of cytochrome c from the mitochondria triggers the oligomerization of Apaf-1 in an ATP/dATP-dependent manner and induces the autoactivation of caspase-9. Active caspase-9 in turn activates downstream effector caspases including caspase -3, -6 and -7. |
| Immunogen | This whole rabbit serum was prepared by repeated immunizations with recombinant His6-tagged human Smac/DIABLO protein (amino acids 56-239). |
| Other Names | rabbit anti-smac antibody, rabbit anti-Diablo antibody, Diablo homolog mitochondrial, Second mitochondria-derived activator of caspase, Smac protein |
| Gene, Accession # | DIABLO, Gene ID: 56616, NCBI: Q9NR28.1, UniProt: Q9NR28 |
| Catalog # | 100-401-244 |
| Price | $475 |
| Order / More Info | Smac/Diablo Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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