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Antigenic Specificity | MITF |
Clone | 21D1418 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein G purified |
Size | 100 µg |
Concentration | 1.0 mg/ml |
Applications | Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-MITF Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with MITF from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-MITF from other sources has not been determined. Anti-MITF antibody detects human MITF. Microphthalmia-associated bHLH-LZ transcription factor (MITF) is a positively acting transcription factor containing a transcription activation domain and a bHLH-LZ domain that mediates DNA-binding and dimerization. Both the transcription activation and bHLH-LZ domains are highly conserved in the closely related TFE3, TFEB and TFEC. MITF can form heterodimers in vitro with the above transcription factors, but not with other bHLH-LZ factors such as Myc, Max or USF. MITF is expressed as multiple isoforms, which share common activation and DNA-binding domains, but differ in the amino-terminal region. MITF is targeted by three kinases: GSK-3beta, Map kinase ERK2 and members of the p90 Rsk family of kinases. Anti-MITF antibody is ideal for investigators involved in kinase, phosphatase, NFkappaB, and signaling research. |
Immunogen | MITF Antibody was produced in mice prepared by repeated immunizations with a synthetic peptide (sequence PSTGLCSPDLVN) corresponding to internal amino acids with human MITF protein. |
Other Names | BHLHE32, Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32 |
Gene, Accession # | MITF, Gene ID: 4286, NCBI: NP_000239.1, UniProt: O75030 |
Catalog # | 200-301-H93 |
Price | $525 |
Order / More Info | MITF Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |