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Antigenic Specificity | NMDA R2C phospho S1096 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µL |
Concentration | n/a |
Applications | Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-NMDA R2C pS1096 antibody is directed against phosphorylated NMDA 2C receptor protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. The antibody is specific for NMDA 2C receptor phosphorylated at S1096. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, human and non-human primates. NMDA R2C pS1096 antibody detects NMDA 2C receptor protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level. Phosphorylation of Ser1096 by PKB on NR2C has been recently demonstrated to regulate NMDA receptor binding to 14-3-3. Anti-NMDA R2C pS1096 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Signal Transduction research. |
Immunogen | Anti-NMDA R2C pS1096 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1096. |
Other Names | Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C |
Gene, Accession # | Grin2c, Gene ID: 24411, UniProt: Q00961 |
Catalog # | 600-401-D95 |
Price | $475 |
Order / More Info | NMDA R2C phospho S1096 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |