Raf-1 phospho S642 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Raf-1 phospho S642 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Raf-1 pS642 antibodies are affinity purified from monospecific antiserum by immunoaffinity purification. This antibody is directed against rat Raf 1 proteins phosphorylated at Ser642. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, chicken, human, mouse and non-human primates. Raf-1 pS642 antibody detects phosphorylated Raf-1. The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK. Previous studies have shown that phosphorylation is required for Raf-1 activation. Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf with two sites participating: Ser301 and Ser642. Anti-Raf-1 pS642 Antibody is ideal for investigators involved in Cancer, Neuroscience, Signal Transduction research. |
| Immunogen | Anti-Raf-1 pS642 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser642 conjugated to KLH. |
| Other Names | RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, cRaf |
| Gene, Accession # | Raf1, Gene ID: 24703, UniProt: P11345 |
| Catalog # | 612-401-E24 |
| Price | $475 |
| Order / More Info | Raf-1 phospho S642 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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