Histone H2AvD phosphoS137 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Histone H2AvD phosphoS137 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | Drosophila |
| Isotype | n/a |
| Format | unconjugated |
| Size | 25 µL |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. H2AvD is vital for viability, but the exact function of variant histones H2A is not known. H2A is a core component of the nucleosome, an octamer containing two molecules each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 bp of DNA. HsAvD is expressed both maternally and zygotically and is found in embryos through to adults (female only). The human homologue, H2AX, is phosphorylated by ATM protein kinase when double strand DNA breaks occur. In mouse, H2AX ''knock out'' mice have an increased incidence of cancer. Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. H2AvD is vital for viability, but the exact function of variant histones H2A is not known. H2A is a core component of the nucleosome, an octamer containing two molecules each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 bp of DNA. HsAvD is expressed both maternally and zygotically and is found in embryos through to adults (female only). The human homologue, H2AX, is phosphorylated by ATM protein kinase when double strand DNA breaks occur. In mouse, H2AX ''knock out'' mice have an increased incidence of cancer. |
| Immunogen | Histone H2AvD pS137 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-Terminal region near amino acids 125-141 of Drosophila melanogaster (fruit fly) H2AvD protein. |
| Other Names | rabbit anti-H2AvD pS137 antibody, rabbit anti-Histone H2A.v pS137 antibody, H2AvD protein antibody, H2A.F/Z, H2A.Z, H2AvD, His2AvD, His2Av |
| Gene, Accession # | His2Av, Gene ID: 43229, NCBI: 17738227, UniProt: P08985 |
| Catalog # | 600-401-914S |
| Price | $125 |
| Order / More Info | Histone H2AvD phosphoS137 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 18407920 // 22406835 // 22993141 // 24055651 // 24352200 // 24686397 // 25794008 // 26502056 // 27019121 // 27072046 // 27094036 // 27514026 // 27687497 // 27729408 // 28000382 // 28040742 // 28441530 // 28663346 // 28743002 // 28819201 // 29233476 // 29362481 // 29720654 // 29925946 // 30036358 // 30061626 // 30093554 // 30230973 // 30612150 // 30735120 // 30947023 // 31002009 // 31269434 // 31315896 // 31364400 // 31495585 // 31504075 // 31506944 // 31708395 // 31941704 // 32259490 // 32402277 // 32561720 // 33357404 // 33725482 // 34919052 // 35036881 // 35355016 // 35484306 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
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