AGO Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | AGO |
| Clone | 2A8 |
| Host Species | Mouse |
| Reactive Species | human, mouse, broad |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 50 µg |
| Concentration | 2.39 mg/ml |
| Applications | Immunohistochemistry, IF Microscopy, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Ago Antibody was purified by Protein A chromatography. This 2A8 monoclonal antibody recognizes all 4 human and mouse Ago proteins while having higher affinity for Ago2. Cross-reactivity with Ago2 from other sources has not been determined. Members of the Argonaute (Ago) protein family are internal to RISC function. Argonaute proteins bind to mature microRNA (miRNAs) and short interfering RNAs (siRNAs) and form the core components of effector complexes that mediate miRNA and siRNA function. Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the single stranded 3' end of the mature miRNA and a PIWI domain that structurally resembles ribonuclease-H and functions to interact with the 5' end of the guide strand. Some argonautes, for example human Ago2, cleave target transcripts directly; argonautes may also recruit additional proteins to achieve translational repression. The human genome encodes eight Argonaute proteins divided by sequence similarities into two families: AGO (with four members present in all mammalian cells and called E1F2C/hAgo in humans), and PIWI (found in the germ line and hematopoietic stem cells). Anti-Ago Antibody is ideal for research in Alternative Splicing, Gene Expression and Gene Silencing. |
| Immunogen | Anti-Ago Antibody was produced in mice by repeated immunization with human Ago2 protein (fusion protein containing amino acids 47-859 of human Ago2). |
| Other Names | Protein argonaute-2, Argonaute2, hAgo2, Argonaute RISC catalytic component 2, Eukaryotic translation initiation factor 2C 2, eIF-2C2, eIF2C 2, PAZ Piwi domain protein, PPD, Protein slicer |
| Gene, Accession # | AGO2, Gene ID: 27161, NCBI: NP_001158095, UniProt: Q9UKV8 |
| Catalog # | 200-301-V04 |
| Price | $485 |
| Order / More Info | AGO Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.