Edit |   |
---|---|
Antigenic Specificity | IKK gamma |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-IKK gamma Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. IKK gamma has no cross response to IKK alpha or IKK beta. Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. The IkB kinase (IKKa and IKKb) phosphorylates IkB and mediates NF-kB activation. A novel molecule in the IKK complex was recently identified and termed IKKgamma/NEMO/FIP3/IKKAP1. IKKgamma interacts with IKKb and is required for the activation of IKK complex and NF-kB by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-kB activation. |
Immunogen | Anti-IKK gamma antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid peptide near the C-terminus of human IKK gamma. |
Other Names | IKK gamma Antibody, IP, IP1, IP2, FIP3, IPD2, NEMO, FIP-3, Fip3p, AMCBX1, ZC2HC9, IKK-gamma, NF-kappa-B essential modulator |
Gene, Accession # | IKBKG, Gene ID: 8517, NCBI: AF074382, UniProt: Q9Y6K9 |
Catalog # | 600-401-BU1 |
Price | $475 |
Order / More Info | IKK gamma Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |