NOXA Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | NOXA |
| Clone | 114C307.1 |
| Host Species | Mouse |
| Reactive Species | human, mouse |
| Isotype | IgG1 kappa |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Noxa Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Noxa from human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Noxa from other sources has not been determined. Anti-Noxa antibody detects human Noxa. Recently, a BH-3 only member of the Bcl-2 family have been identified in human and mouse and designated as Noxa (for damage). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Noxa cDNA codes for a 103-amino acid protein. The coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as, Bcl-XL and Mcl-1. Oda et al. have also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis suggesting that Noxa may represent a mediator of p53-dependent apoptosis. Anti-Noxa antibody is ideal for investigators involved in apoptosis research. |
| Immunogen | Noxa Antibody was produced in mice prepared by repeated immunizations with the human protein Noxa. |
| Other Names | NOXA, Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa |
| Gene, Accession # | PMAIP1, Gene ID: 5366, NCBI: NP_066950.1, UniProt: Q13794 |
| Catalog # | 200-301-H98 |
| Price | $495 |
| Order / More Info | NOXA Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 28079889 // 32015503 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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