Progesterone Receptor phospho S294 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Progesterone Receptor phospho S294 |
| Clone | 608 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Progesterone Receptor pS294 (Mouse) Monoclonal Antibody is Protein G purified from cell culture supernatant. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. This phospho specific monoclonal antibody is specific for phosphorylated human pS294. BLAST analysis suggests cross-reactivity with progesterone receptor from non-human primates based on 100% sequence homology. There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor. Anti-Progesterone Receptor pS294 (Mouse) Monoclonal Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Cancer research. |
| Immunogen | Anti-Progesterone Receptor pS294 (Mouse) Monoclonal Antibody was produced in mouse by repeated immunizations with Progesterone Receptor pS294- Synthetic peptide corresponding to amino acid residues surrounding Ser294 of the human progesterone receptor protein. |
| Other Names | mouse anti-Progesterone Receptor phospho S294 Antibody, mouse anti-Progesterone Receptor pS294 antibody, PR, Nuclear receptor subfamily 3 group C member 3 |
| Gene, Accession # | PGR, Gene ID: 5241, NCBI: AAA60081.1, UniProt: P06401 |
| Catalog # | 209-301-E17 |
| Price | $485 |
| Order / More Info | Progesterone Receptor phospho S294 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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