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Antigenic Specificity | PRMT6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | serum |
Size | 200 µL |
Concentration | n/a |
Applications | Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-PRMT6 Antibody is sera. A BLAST analysis was used to suggest cross-reactivity with PRMT6 from human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-PRMT6 from other sources has not been determined. Anti-PRMT6 Antibody detects human PRMT6. Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT6 was identified by searching the human genome for protein arginine N-methyltransferase (PRMT) family members. PRMT6 cDNA codes for a protein of approximate molecular weight of 42 kDa consisting of a catalytic core sequence common to other PRMT enzymes. PRMT6 demonstrates type I PRMT activity, capable of forming both >NG-monomethylarginine and asymmetric >NG,NG-dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. A comparison of substrate specificity reveals that PRMT6 is functionally distinct from two previously characterized type I enzymes, PRMT1 and PRMT4. In addition to methylating substrate proteins, PRMT6 displays automethylation activity. GFP-fusion protein expression in the transfected cell lines suggest that PRMT6 localizes in the nucleus. Anti-PRM6 is ideal for researchers interested in NFkappaB research. |
Immunogen | PRMT6 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to internal amino acids of human PRMT6 protein. |
Other Names | HRMT1L6, Protein arginine N-methyltransferase 6, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6 |
Gene, Accession # | PRMT6, Gene ID: 55170, NCBI: NP_060607.2, UniProt: Q96LA8 |
Catalog # | 100-401-I04 |
Price | $495 |
Order / More Info | PRMT6 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |