PUMA Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | PUMA |
| Clone | 10C5G1 |
| Host Species | Mouse |
| Reactive Species | human, rat |
| Isotype | IgG1 |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-PUMA Monoclonal Antibody was immunoaffinity chromatography purified IgG. Cross reactivity with PUMA [10C5G1] from other sources has not been determined. Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAa and PUMAb. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
| Immunogen | Anti-PUMA antibody was produced In mice by repeated immunizations with a recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha. |
| Other Names | PUMA Antibody [10C5G1], JFY1, PUMA, JFY-1 |
| Gene, Accession # | BBC3, Gene ID: 27113, NCBI: NP_055232, UniProt: Q96PG8 |
| Catalog # | 200-301-DV1 |
| Price | $485 |
| Order / More Info | PUMA Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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