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Antigenic Specificity | Trail |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Trail Antibody is affinity chromatography purified via peptide column. A BLAST analysis was used to suggest cross-reactivity with Trail with Human based on 100% homology with the immunizing sequence. Cross-reactivity with Trail from other sources has not been determined. Trail Antibody detects cytokines in the TNF family. Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand)1, TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells. Anti-Trail antibodies are ideal for investigators involved in Cytokines and Growth Factors and Apoptosis research. |
Immunogen | Trail Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the c-terminus of human TRAIL. |
Other Names | Apo-2L, TRAIL |
Gene, Accession # | TNFSF10, Gene ID: 8743, NCBI: NP_003801, UniProt: P50591 |
Catalog # | 200-401-H27 |
Price | $475 |
Order / More Info | Trail Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |