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Antigenic Specificity | FLT3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-FLT3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least three isoforms of FLT3 are known to exist; this antibody will detect all isoforms. FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity. |
Immunogen | Anti-FLT3 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the internal region of human FLT3. |
Other Names | FLT3 Antibody, FLK2, STK1, CD135, FLK-2, FLK2, Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor |
Gene, Accession # | FLT3, Gene ID: 2322, NCBI: NP_004110, UniProt: P36888 |
Catalog # | 600-401-BF5 |
Price | $475 |
Order / More Info | FLT3 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |