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Antigenic Specificity | TIM-4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-TIM-4 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with TIM-4 from other sources has not been determined. The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma. |
Immunogen | Anti-TIM-4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the internal region of human TIM-4. |
Other Names | TIM-4 Antibody, TIM4, SMUCKLER, TIM4, T-cell immunoglobulin and mucin domain-containing protein 4, T-cell immunoglobulin mucin receptor 4, TIMD-4 |
Gene, Accession # | TIMD4, Gene ID: 91937, NCBI: NP_001140198.1, UniProt: Q96H15 |
Catalog # | 600-401-FE9 |
Price | $475 |
Order / More Info | TIM-4 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |