Brn3b Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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|---|---|
| Antigenic Specificity | Brn3b |
| Clone | polyclonal |
| Host Species | Goat |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1.05 mg/ml |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This affinity purified antibody is directed against mouse Brn3b. This product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to rat and 91.7% to human. Brn3b (Brain-Specific Homeobox/POU Domain Protein 3B) or POU4F2 (POU Class 4 Homeobox 2) is a DNA-binding transcriptional regulator and coregulator that recognizes and binds to the consensus octamer binding site 5-AT[A/T]A[T/A]T[A/T]A-3 in promoter of target genes. Brn3b plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. It cooperates with the transcription factor ISL1 to achieve RGC fate specification in the developing retina. And plays a role in RGC axon formation and guidance by regulating gene expression of specific target genes. Brn3b plays a role in TNFSF11-mediated terminal osteoclast differentiation. It binds chromatin at promoter region of target genes. It acts either as a transcriptional activator or repressor. It plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. It is involved in tumor breast progression and invasion. Brn3b also plays a role either as a transcriptional coactivator or corepressor. Anti-Brn3b Antibody is useful for researchers interested in breast cancer research, transcription factor activity, and DNA binding. |
| Immunogen | Anti-Brn3b antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a near N-terminal portion of mouse Pou4f2 conjugated to Keyhole Limpet Hemocyanin (KLH). |
| Other Names | Goat Anti-Brn3b Antibody, Goat Anti-Pou4f2 Antibody, POU domain, class 4, transcription factor 2, Brain-specific homeobox/POU domain protein 3B, Brn-3B, Brain-3B, Brn-3.2 |
| Gene, Accession # | Pou4f2, Gene ID: 18997, NCBI: NP-620394.2, UniProt: Q63934 |
| Catalog # | 600-101-MJ0 |
| Price | $475 |
| Order / More Info | Brn3b Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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