PSD95 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | PSD95 |
| Clone | S28-43 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG2a |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1mg/ml |
| Applications | Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-PSD-95 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with PSD-95 from Mouse, Human, and rat based on 100% homology with the immunizing sequence. Cross-reactivity with PSD-95 from other sources has not been determined. Ion Channels research. Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex. These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins. Thus different PDZ domains of PSD-95 might be specialized for distinct functions. PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning. Mutations in PSD95 are associated with autism. |
| Immunogen | PSD95 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to an internal region of human PSD95/SAP90. |
| Other Names | DLG4, SAP90, Synapse-associated protein 90, Postsynaptic density protein 95, Disks large homolog 4, PSD-95, SAP-90, PSD95 |
| Gene, Accession # | DLG4, Gene ID: 1742, NCBI: NP_001122299.1, UniProt: P78352 |
| Catalog # | 200-301-G34 |
| Price | $485 |
| Order / More Info | PSD95 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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