Edit |   |
---|---|
Antigenic Specificity | IL-1RL2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.0 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-IL-1RL2 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. IL-1RL2 antibody is human, mouse and rat reactive. At least three isoforms of IL-1RL2 are known to exist; this antibody will detect all three isoforms. IL-1RL2 antibody is predicted to not cross-react with IL-1R or IL-1RL1. IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity (1). Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway (2). IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response (3). |
Immunogen | Anti-IL-1RL2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid peptide near the internal region of human IL-1RL2. |
Other Names | IL-1RL2 Antibody, IL-36R, IL1RRP2, IL-1Rrp2, IL1R-rp2, Interleukin-1 receptor-like 2, IL-36 receptor, IL-36R |
Gene, Accession # | IL1RL2, Gene ID: 8808, NCBI: NP_003845, UniProt: Q9HB29 |
Catalog # | 600-401-BV4 |
Price | $475 |
Order / More Info | IL-1RL2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |