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Antigenic Specificity | MYCT1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-MYCT1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least two isoforms of MYCT1 are known to exist; this antibody will detect both isoforms. MYCT1 was initially identified as a novel target of the c-Myc oncogene in myeloid cells. It is a widely expressed nuclear protein whose overexpression can promote apoptosis, alteration of morphology, enhancement of anchorage-independent cell growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. MYCT1 binds to the promoters of several c-Myc-regulated genes and it has been suggested that the phenotypes seen in MYCT1-overexpressing cells are a result of the deregulation of these genes. RUNX1-ETO, a fusion protein made up of RUNX1 and ETO, is thought to deregulate the proliferation and responsiveness of human hematopoietic progenitor cells downstream of MYCT1. |
Immunogen | Anti-MYCT1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the C-terminus of human MYCT1. |
Other Names | MYCT1 Antibody, MTLC, MTLC, MTMC1, Myc target protein 1, Myc target in myeloid cells protein 1 |
Gene, Accession # | MYCT1, Gene ID: 80177, NCBI: NP_079383, UniProt: Q8N699 |
Catalog # | 600-401-CW4 |
Price | $475 |
Order / More Info | MYCT1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |