Edit |   |
---|---|
Antigenic Specificity | LRRTM2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-LRRTM2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. LRRTM2 antibody is predicted to not cross-react with other LRRTM family members. The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development. |
Immunogen | Anti-LRRTM2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the C-terminus of human LRRTM2. |
Other Names | LRRTM2 Antibody, KIAA0416, LRRN2, Leucine-rich repeat transmembrane neuronal protein 2, Leucine-rich repeat neuronal 2 protein |
Gene, Accession # | LRRTM2, Gene ID: 26045, NCBI: EAW62125, UniProt: O43300 |
Catalog # | 600-401-CN0 |
Price | $475 |
Order / More Info | LRRTM2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |