Mcl-1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Mcl-1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1.1mg/ml |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This affinity-purified antibody was prepared from monospecific antiserum by immunoaffinity chromatography using synthetic peptide coupled to agarose beads followed by cross adsorption to remove any unwanted reactivity. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. Regulated apoptosis is essential for both the development and the subsequent maintenance of the immune system. Interleukins, including IL-2, IL-4, IL-7 and IL-15, heavily influence lymphocyte survival during the vulnerable stages of VDJ rearrangement and later in ensuring cellular homeostasis, but the genes specifically responsible for the development and maintenance of lymphocytes have not been identified. The Anti apoptotic protein Mcl-1 (myeloid cell leukemia sequence 1 (BCL2-related)) is an attractive candidate, as it is highly regulated, appears to enhance short-term survival and functions at an apical step in genotoxic deaths. However, Mcl-1 deficiency results in peri-implantation lethality. Mice, conditional for Mcl-1, display a profound reduction in B and T lymphocytes when Mcl-1 is removed. Deletion of Mcl-1 during early lymphocyte differentiation increases apoptosis and arrests the development at pro-B-cell and double negative T-cell stages. Induced deletion of Mcl-1 in peripheral B- and T-cell populations results in their rapid loss. Moreover, IL-7 both induces and requires Mcl-1 to mediate lymphocyte survival. Mcl-1 is essential both early in lymphoid development and later on in the maintenance of mature lymphocytes. |
| Immunogen | This affinity purified antibody was purified from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to an internal region of mouse Mcl-1 conjugated to Keyhole Limpet Hemocyanin (KLH). |
| Other Names | rabbit anti-Mcl-1 antibody, Mcl1, Mcl 1, Bcl 2 related protein EAT/mcl1 antibody, Bcl2 related antibody, EAT antibody, Induced myeloid leukemia cell differentiation protein Mcl-1 antibody |
| Gene, Accession # | Mcl1, Gene ID: 17210, NCBI: P97287.3, UniProt: P97287 |
| Catalog # | 600-401-394 |
| Price | $475 |
| Order / More Info | Mcl-1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 16563162 // 17618288 // 18048346 // 18089817 // 18566418 // 18835564 // 19060243 // 19200886 // 19676108 // 19734538 // 19839062 // 19946273 // 20142358 // 21041309 // 21632463 // 21642990 // 21958558 // 22240894 // 22357134 // 22976837 // 23145067 // 23788623 // 23824576 // 23933517 // 23954788 // 24263101 // 24427286 // 25146925 // 25340740 // 25752611 // 25950485 // 26045049 // 26219338 // 26344567 // 26450454 // 26769846 // 26822034 // 26890142 // 27098698 // 27159560 // 27458457 // 27537523 // 27665925 // 27694901 // 27806040 // 28085151 // 28553951 // 28982759 // 29141222 // 29149594 // 29498802 // 29499131 // 29686375 // 29855540 // 30257201 // 30261081 // 30281024 // 30361616 // 30770875 // 30894069 // 30894677 // 31767615 // 32015322 // 32094511 // 32513923 // 32612106 // 32717194 // 33239784 // 33288732 // 33310872 // 33484913 // 33512417 // 33787344 // 33959612 // 34778891 // 34926454 // 35563775 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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